Meta description :There are no Rh antigens (proteins) on the red blood cell in the golden blood type or Rh no blood group (RBC). This is the rarest blood group in the world, with less than 50 people having it. It was discovered in Aboriginal Australians for the first time.
The concern with the golden blood group is the unbelievably scarces and difficulty in obtaining Rh null donations. If you need your blood, a Rh Null person must rely on a small network of regular Rh Null donors around the world. Only nine active donors are active in this blood group worldwide. This is the most valuable blood type in the world, which is why this is called the golden blood.
Our red blood cells have proteins on their surface called antigens. We have either A, B, O or AB blood type depending on the antigen present. The Rh-positive or Rh-negative system is distinct from ABO depending on the presence or absence of the 'Rh-D' factor on the cells.
The person lacks all Rh antigens in the golden blood group, while the person with an Rh negative blood group does not have only RhD antigen
Genetic mutation appears to be the cause of the golden blood group (spontaneous change in the gene). Mutations in the RHAG gene, which codes for the Rh-associated glycoprotein, are common. The Rh antigens must be directed to the RBC membrane by this protein.
The RHAG mutation is frequently linked to a condition known as hereditary stomatocytosis. Long-term, moderate hemolytic anemia and accelerated RBC breakdown can occur in these people. The Rh-null phenotype can also be present in people who are born with certain anemias.
Increased risk for golden blood group may be as follows:
Consanguineous marriage is a term used to describe a marriage between two people ( a marriage between cousins, brother-sister, or anybody who is a near or distant relative)
Genes from the autosomal chromosome (abnormal genes, which have disease traits, passed down through families)RHD and RHCE, as well as RHAG, have undergone changes or have been completely removed.
What are the dangers of having a golden blood type?
Individuals with Rh null or gold types may usually have
Minor to mild hemolytic anemia since birth: This causes RBCs to be destroyed more quickly. This can cause low levels of hemoglobin to cause paleness and fatigue. This happens because of structural defects in RBCs such as
Shaped as a mouth or slit
Red cell slight elastic structure
A red cell abnormal coverage
Increased fragility due to the lack of Rh antigen
Altered blood cell volume
Challenges of blood transfusion:
These people could have difficulties while transfusing their blood. If this person's blood is exposed to Rh antigens (proteins on the surface of RBCs) from other people's blood, autoantibodies are rapidly formed, and a severe transfusion reaction may occur. As a result, hospitals must have unique protocols in place for these patients, as well as swift response management.
Pregnancy Rh incompatibility:
If your mum is Rh null and the baby is Rh-positive and the baby's mother has positive blood sensitization. The mother's blood may then produce proteins known as anticipated, that may target future pregnancies or lead to abortion or miscarriage.
Hemolytic crisis:
multiple studies have demonstrated that any infection or sepsis has caused massive bleeding, subsequent kidney failure, and other complications in such people.
Is it possible to donate golden blood type?
Yes, golden blood can be given as a donation. A person with Rh null blood is called a universal donor RBCs lack antigens, and this blood can be donated to anyone with unusual blood types within the Rh systems.
Since it lacks common antigens, this blood is ideal for transfusion because it can be taken by everyone who requires a transfusion without the risk of a blood transfusion reaction. However, because of its rarity, finding this type becomes incredibly tough.
Rh null, on the other hand, is usually not good for those who have it. If they ever need a blood transfusion, any blood that contains the Rh antigen will almost certainly result in a transfusion response.
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